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Additional benefits of taking a GLP-1 weekly was also shown to improve cardiometabolic health, which includes a reduction in insulin resistance and a reduction in metabolic disorder and less risk for cardiovascular disease

However, the effect of C677T polymorphisms of MTHFR on cognitive function was not significant in normal subjects as a longitudinal cognitive study showed that the MTHFR C677T polymorphism was not associated with cognitive performance at baseline or over 12 years 49

Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

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Avoiding high-fat foods during the adaptation phase helps, as fat slows digestion further and can worsen discomfort